Biomarkers; Hemorrhage; Proteomics; Pyridines; Thiazoles; Thromboembolism; Atrial Fibrillation/complications; Atrial Fibrillation/drug therapy; Biomarkers/analysis; Biomarkers/metabolism; Factor Xa Inhibitors/administration & dosage; Factor Xa Inhibitors/adverse effects; Female; Hemorrhage/blood; Hemorrhage/chemically induced; Hemorrhage/prevention & control; Humans; Male; Middle Aged; Proteomics/methods; Proteomics/trends; Pyridines/administration & dosage; Pyridines/adverse effects; Randomized Controlled Trials as Topic; Risk Assessment/methods; Risk Factors; Thiazoles/administration & dosage; Thiazoles/adverse effects; Thromboembolism/blood; Thromboembolism/diagnosis; Thromboembolism/prevention & control