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A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model.
Peter, Antonia Sophia; Roth, Edith; Schulz, Sebastian R; Fraedrich, Kirsten; Steinmetz, Tobit; Damm, Dominik; Hauke, Manuela; Richel, Elie; Mueller-Schmucker, Sandra; Habenicht, Katharina; Eberlein, Valentina; Issmail, Leila; Uhlig, Nadja; Dolles, Simon; Grüner, Eva; Peterhoff, David; Ciesek, Sandra; Hoffmann, Markus; Pöhlmann, Stefan; McKay, Paul F; Shattock, Robin J; Wölfel, Roman; Socher, Eileen; Wagner, Ralf; Eichler, Jutta; Sticht, Heinrich; Schuh, Wolfgang; Neipel, Frank; Ensser, Armin; Mielenz, Dirk; Tenbusch, Matthias; Winkler, Thomas H; Grunwald, Thomas; Überla, Klaus; Jäck, Hans-Martin.
Affiliation
  • Peter AS; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Roth E; Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Schulz SR; Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Fraedrich K; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Steinmetz T; Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Damm D; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Hauke M; Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Richel E; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Mueller-Schmucker S; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Habenicht K; Division of Genetics, Department Biology, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Eberlein V; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
  • Issmail L; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
  • Uhlig N; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
  • Dolles S; Department of Chemistry & Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Grüner E; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Peterhoff D; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, Regensburg, Germany.
  • Ciesek S; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
  • Hoffmann M; Institute of Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
  • Pöhlmann S; German Centre for Infection Research, External Partner Site, Frankfurt, Germany.
  • McKay PF; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Frankfurt, Germany.
  • Shattock RJ; Infection Biology Unit, German Primate Center, Göttingen, Germany.
  • Wölfel R; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
  • Socher E; Infection Biology Unit, German Primate Center, Göttingen, Germany.
  • Wagner R; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
  • Eichler J; Department of Infectious Diseases, Imperial College London, London, UK.
  • Sticht H; Department of Infectious Diseases, Imperial College London, London, UK.
  • Schuh W; Bundeswehr Institute of Microbiology, Munich, Germany.
  • Neipel F; German Center for Infection Research, Partner Site Munich, Munich, Germany.
  • Ensser A; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Mielenz D; Division of Bioinformatics, Institute of Biochemistry, Emil-Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Tenbusch M; Institute of Anatomy, Functional and Clinical Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Winkler TH; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, Regensburg, Germany.
  • Grunwald T; Department of Chemistry & Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Überla K; Division of Bioinformatics, Institute of Biochemistry, Emil-Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Jäck HM; Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Eur J Immunol ; 52(5): 770-783, 2022 05.
Article in En | MEDLINE | ID: mdl-34355795
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2022 Document type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2022 Document type: Article Affiliation country: Germany