Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and apoptosis regression.

Ezzat, Shahira M; Abdallah, Heba M I; Yassen, Noha N; Radwan, Rasha A; Mostafa, Eman S; Salama, Maha M; Salem, Mohamed A

Ezzat, Shahira M; Abdallah, Heba M I; Yassen, Noha N; Radwan, Rasha A; Mostafa, Eman S; Salama, Maha M; Salem, Mohamed A.

Affiliation

Ezzat SM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt. Electronic address: shahira.ezzat@pharma.cu.edu.eg.
Abdallah HMI; Department of Pharmacology, Medical Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Cairo, Egypt. Electronic address: hm.abdullah@nrc.sci.eg.
Yassen NN; Department of Pathology, Medical Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Cairo, Egypt. Electronic address: nn.yassin@nrc.sci.eg.
Radwan RA; Department of Biochemistry, Faculty of Pharmacy, Sinai University, East Kantara Branch, New City El Ismailia 41611, Egypt. Electronic address: rashaaradwan2011@gmail.com.
Mostafa ES; Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt. Electronic address: emostafa@msa.eun.eg.
Salama MM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, The British University in Egypt, El Sherouk City, Suez Desert Road, Cairo 11837, Egypt. Electronic address: maha.salama@pharma.cu.edu.eg.
Salem MA; Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr st., Shibin Elkom 32511, Menoufia, Egypt. Electronic address: mohamed.salem@phrm.menofia.edu.eg.

Biomed Pharmacother ; 142: 111948, 2021 Oct.

Article in En | MEDLINE | ID: mdl-34385108

Subject(s)

Antioxidants/pharmacology; Diabetes Mellitus, Experimental/drug therapy; Diabetic Nephropathies/drug therapy; Hypoglycemic Agents/pharmacology; Phenols/pharmacology; Physalis/chemistry; Plant Extracts/pharmacology; Animals; Antioxidants/therapeutic use; Antioxidants/toxicity; Apoptosis/drug effects; Autophagy/drug effects; Blood Glucose/drug effects; Body Weight/drug effects; Diabetes Mellitus, Experimental/complications; Diabetic Nephropathies/complications; Diabetic Nephropathies/pathology; Fruit/chemistry; Glycogen/metabolism; Hypoglycemic Agents/isolation & purification; Hypoglycemic Agents/therapeutic use; Hypoglycemic Agents/toxicity; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Pancreas/drug effects; Pancreas/metabolism; Pancreas/pathology; Phenols/isolation & purification; Phenols/therapeutic use; Phenols/toxicity; Plant Extracts/isolation & purification; Plant Extracts/therapeutic use; Plant Extracts/toxicity; Rats, Wistar; Tumor Suppressor Protein p53/metabolism

Key words

AMPK/mTOR pathway; Apoptosis; Autophagy; Diabetic nephropathy; Golden berry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Plant Extracts / Physalis / Diabetes Mellitus, Experimental / Diabetic Nephropathies / Hypoglycemic Agents / Antioxidants Language: En Journal: Biomed Pharmacother Year: 2021 Document type: Article Country of publication: France

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