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A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue.
Juvekar, Vinayak; Cho, Myoung Ki; Lee, Hyo Won; Lee, Dong Joon; Kang, Hyuk; Song, Ju Man; Je, Jong Tae; Kim, Hwan Myung.
Affiliation
  • Juvekar V; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
  • Cho MK; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
  • Lee HW; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
  • Lee DJ; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
  • Kang H; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
  • Song JM; Giheung R&D Center, SFC Co., Ltd, Yongin, 16953, South Korea. jtje@sfc-dye.com.
  • Je JT; Giheung R&D Center, SFC Co., Ltd, Yongin, 16953, South Korea. jtje@sfc-dye.com.
  • Kim HM; Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
Chem Commun (Camb) ; 57(71): 8929-8932, 2021 Sep 06.
Article in En | MEDLINE | ID: mdl-34397047
ABSTRACT
A cyclocyanine (CC)-based organic small molecule two-photon (TP) fluorescent probe (CCNa1) was developed for mitochondrial sodium ion sensing. CCNa1 exhibits a low solvatochromic shift and strong TP fluorescence enhancement at 575 nm upon binding to Na+ and is insensitive to other metal ions and to pH. CCNa1 demonstrated fast cell loading ability, biocompatibility, and sensitive response to mitochondrial Na+ influx in live cells and mouse brain tissue.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium / Fluorescent Dyes / Mitochondria Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: South Korea
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium / Fluorescent Dyes / Mitochondria Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: South Korea