[Rifampicin pharmacokinetics in experimental hepatitis]. / Izuchenie farmakokinetiki rifampitsina pri éksperimental'nom gepatite.

ABSTRACT

Rifampicin pharmacokinetics in rats with acute affection of the liver with carbon tetrachloride did not alter. Chronic affection with carbon tetrachloride resulted in retarded elimination of the antibiotic from blood. There was observed no relationship between increased activities of transamination enzymes such as alanine aminotransferase and aspartate aminotransferase in blood serum of animals and changes in rifampicin pharmacokinetics.