Electrical impedance tomography detects changes in ventilation after airway clearance in spinal muscular atrophy type I.
Respir Physiol Neurobiol
; 294: 103773, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34400355
ABSTRACT
The effect of mechanical insufflation-exsufflation (MIE) for airway clearance in patients with spinal muscular atrophy type I (SMA-I) on the distribution of ventilation in the lung is unknown, as is the duration of its beneficial effects. A pilot study to investigate the feasibility of using three dimensional (3-D) electrical impedance tomography (EIT) images to estimate lung volumes pre- and post-MIE for assessing the effectiveness of mechanical insufflation-exsufflation (MIE) was conducted in 6 pediatric patients with SMA-I in the neuromuscular clinic at Children's Hospital Colorado. EIT data were collected before, during, and after the MIE procedure on two rows of 16 electrodes placed around the chest. Lung volumes were computed from the images and compared before, during, and after the MIE procedure to assess the ability of EIT to estimate changes in lung volume during insufflation and exsufflation. Images of pulsatile pulmonary perfusion were computed in subjects able to perform breath-holding. In four of the six subjects, lung volumes during tidal breathing increased after MIE (average change from pre to post MIE was 58.8±55.1 mL). The time-dependent plots of lung volume computed from the EIT data clearly show when the MIE device insufflates and exsufflates air and the rest periods between mechanical coughs. Images of pulmonary pulsatile perfusion were computed from data collected during breathing pauses. The results suggest that EIT holds promise for estimating lung volumes and ventilation/perfusion mismatch, both of which are useful for assessing the effectiveness of MIE in clearing mucus plugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insufflation
/
Spinal Muscular Atrophies of Childhood
/
Pulmonary Ventilation
/
Airway Obstruction
Limits:
Child
/
Humans
Language:
En
Journal:
Respir Physiol Neurobiol
Year:
2021
Document type:
Article
Affiliation country:
United States