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A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold-labeled venetoclax, from chemistry to the clinic.
Alaarg, Amr; Menon, Rajeev; Rizzo, David; Liu, Yemin; Bien, Jeffrey; Elkinton, Tricia; Grieme, Timothy; Asmus, Lutz R; Salem, Ahmed Hamed.
Affiliation
  • Alaarg A; Drug Product Development, AbbVie Inc., North Chicago, Illinois, USA.
  • Menon R; Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, Illinois, USA.
  • Rizzo D; DMPK-BA, AbbVie Inc, North Chicago, Illinois, USA.
  • Liu Y; Development Sciences Analytical R&D, AbbVie Inc., North Chicago, Illinois, USA.
  • Bien J; Development Sciences Program Management & Sourcing, North Chicago, Illinois, USA.
  • Elkinton T; AbbVie Clinical Pharmacology Research Unit, Grayslake, Illinois, USA.
  • Grieme T; Process R&D AbbVie Inc., North Chicago, Illinois, USA.
  • Asmus LR; Drug Product Development, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.
  • Salem AH; Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, Illinois, USA.
Clin Transl Sci ; 15(1): 244-254, 2022 01.
Article in En | MEDLINE | ID: mdl-34416076
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Biological Availability / Bridged Bicyclo Compounds, Heterocyclic Type of study: Prognostic_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: Clin Transl Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Biological Availability / Bridged Bicyclo Compounds, Heterocyclic Type of study: Prognostic_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: Clin Transl Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States