Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil.
Int J Parasitol Drugs Drug Resist
; 17: 80-83, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34418583
ABSTRACT
This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC50 values ranging from 0.28 to 22.34⯵gâ¯mL-1, and weakly cytotoxic against the human cell line WI-26-VA4 with CC50 valuesâ¯>â¯89⯵gâ¯mL-1, thus displaying selectivity indices (SI) equal or higher than 17. Interestingly, some SI values exceeded 1,000. The highly potent and selective antiplasmodial activity of the assessed marine sponges is reported for the first time in this study.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Porifera
/
Antimalarials
Limits:
Animals
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Int J Parasitol Drugs Drug Resist
Year:
2021
Document type:
Article
Affiliation country:
Brazil
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS