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Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Albanese, Federica; Mercatelli, Daniela; Finetti, Luca; Lamonaca, Giulia; Pizzi, Sara; Shimshek, Derya R; Bernacchia, Giovanni; Morari, Michele.
Affiliation
  • Albanese F; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: federica.albanese@unife.it.
  • Mercatelli D; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, 44121 Ferrara, Italy; Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, 44121 Ferrara, Italy. Electronic address: daniela.mercatelli@unife.it.
  • Finetti L; Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: luca.finetti@unife.it.
  • Lamonaca G; Institute for Biomedicine, Eurac Research-Affiliated Institute of the University of Lübeck, 39100 Bolzano, Italy. Electronic address: giulia.lamonaca@eurac.edu.
  • Pizzi S; Institute for Biomedicine, Eurac Research-Affiliated Institute of the University of Lübeck, 39100 Bolzano, Italy. Electronic address: sara.pizzi@eurac.edu.
  • Shimshek DR; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland. Electronic address: derya.shimshek@novartis.com.
  • Bernacchia G; Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: giovanni.bernacchia@unife.it.
  • Morari M; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: m.morari@unife.it.
Neurobiol Dis ; 159: 105487, 2021 11.
Article in En | MEDLINE | ID: mdl-34419621
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Autophagy / Aging / Neostriatum / Alpha-Synuclein / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Glucosylceramidase / Neurons Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2021 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Autophagy / Aging / Neostriatum / Alpha-Synuclein / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Glucosylceramidase / Neurons Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2021 Document type: Article Country of publication: United States