Association of human leukocyte antigen-B*13:01 with dapsone-induced liver injury.
Br J Clin Pharmacol
; 88(3): 1369-1372, 2022 03.
Article
in En
| MEDLINE
| ID: mdl-34427944
ABSTRACT
Human leukocyte antigens (HLA) have been linked to adverse drug reactions. Generally, HLA association is phenotype specific and is related to either liver or skin injury. HLA-A*1301 has been linked to dapsone-induced severe cutaneous drug reactions and its role in drug-induced liver injury (DILI) is unclear. In our series, all of the four patients with immunoallergic dapsone DILI were carrying HLA-B*1301 compared to its prevalence of 1-12% among Indians. HLA-B*1301 plays a role not only in dapsone-induced severe cutaneous adverse reaction (SCAR) but also in dapsone-induced liver injury with immunoallergic features and highlights the role of adaptive immune response in the pathogenesis of both liver and skin injury and associated other organ involvement.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chemical and Drug Induced Liver Injury
/
Chemical and Drug Induced Liver Injury, Chronic
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Br J Clin Pharmacol
Year:
2022
Document type:
Article
Affiliation country:
India