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Aseptic cystitis induced by nivolumab and ipilimumab combination for metastatic melanoma.
Schneider, Sophie; Alezra, Eric; Yacoub, Mokrane; Ducharme, Océane; Gerard, Emilie; Dutriaux, Caroline; Prey, Sorilla.
Affiliation
  • Schneider S; CHU de Bordeaux, Service de Dermatologie.
  • Alezra E; CHU de Bordeaux, Service de chirurgie urologique.
  • Yacoub M; CHU de Bordeaux, Service de Pathologie.
  • Ducharme O; CHU de Bordeaux, Service de Dermatologie.
  • Gerard E; CHU de Bordeaux, Service de Dermatologie.
  • Dutriaux C; CHU de Bordeaux, Service de Dermatologie.
  • Prey S; Univ. Bordeaux, Inserm U-1035, Bordeaux, France.
Melanoma Res ; 31(5): 487-489, 2021 10 01.
Article in En | MEDLINE | ID: mdl-34433197
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. Combination of ICI with ipilimumab cytotoxic T-lymphocyte antigen-4 and nivolumab [anti-programmed cell death-1 (PD-1)] improves tumoral response compared to anti-PD1 monotherapy in melanoma patients, but is associated with more severe and multiple immune-related adverse events. We report the first case of aseptic cystitis induced by ipilimumab and nivolumab combination in a 61-year-old melanoma patient. She described after two infusions, diarrhea, pollakiuria, intense bladder pain, urinary urgency, and nocturia. Repeated negative urine culture tests led to perform cystoscopy. Mucosal bladder biopsies showed lymphocytic T-cells infiltration in intraepithelial and in subepithelial connective tissue, which were consistent with the diagnosis of immune-related aseptic cystitis. Aseptic cystitis is a rare and poorly known side-effect related to ICI. Only four other cases with anti-PD1 monotherapy were found in literature, only in Japanese patients. It simulates bacterial cystitis with negative urinary tests, and is often associated with atypical symptoms like diarrhea, which may delay the diagnosis. Oral steroids appear to be the most efficient therapeutic options.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Cystitis / Drug-Related Side Effects and Adverse Reactions / Melanoma Type of study: Etiology_studies / Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Melanoma Res Journal subject: NEOPLASIAS Year: 2021 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Cystitis / Drug-Related Side Effects and Adverse Reactions / Melanoma Type of study: Etiology_studies / Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Melanoma Res Journal subject: NEOPLASIAS Year: 2021 Document type: Article Country of publication: United kingdom