Novel glutamic acid derivatives from the bulbs of Fritillaria verticillate Willd and their antitumor activities.
Fitoterapia
; 154: 105022, 2021 Oct.
Article
in En
| MEDLINE
| ID: mdl-34438014
ABSTRACT
Four previously undescribed glutamic acid derivatives, verticillamines A-D (1-4), together with six known compounds (5-10) were isolated from the bulbs of Fritillaria verticillate Willd. The structures of (1-10) were established on the basis of UV, IR, MS, 1D and 2D NMR, and the absolute configurations of compounds (1-4) were determined by calculated ECD methods. Among them, compounds (1-3) were rare 2-methyl-γ-lactam alkaloid derivatives. Moreover, both γ-lactam alkaloids (1-5) and pyrrolidine alkaloids (6-7) were discovered in Fritillaria for the first time. Compound 8 exhibited moderate cytotoxic activities against A2780 and HepG 2 cells, with IC50 values of 11.7 ± 5.2 µM and 25.6 ± 2.8 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fritillaria
/
Glutamates
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2021
Document type:
Article
Affiliation country:
China