Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation.

Mohamed, Reem A; Abdallah, Dalaal M; El-Brairy, Amany I; Ahmed, Kawkab A; El-Abhar, Hanan S

Mohamed, Reem A; Abdallah, Dalaal M; El-Brairy, Amany I; Ahmed, Kawkab A; El-Abhar, Hanan S.

Affiliation

Mohamed RA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts, 26 July Mehwar Road Intersection with Wahat Road, 6th of October City, Giza 12451, Egypt.
Abdallah DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini Str., Cairo 11562, Egypt.
El-Brairy AI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts, 26 July Mehwar Road Intersection with Wahat Road, 6th of October City, Giza 12451, Egypt.
Ahmed KA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
El-Abhar HS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini Str., Cairo 11562, Egypt.

Molecules ; 26(16)2021 Aug 21.

Article in En | MEDLINE | ID: mdl-34443654

Subject(s)

Aconitine/analogs & derivatives; Alzheimer Disease/drug therapy; Inflammation/drug therapy; Palonosetron/pharmacology; Aconitine/pharmacology; Alzheimer Disease/etiology; Alzheimer Disease/genetics; Alzheimer Disease/pathology; Amyloid beta-Peptides/genetics; Animals; CARD Signaling Adaptor Proteins/genetics; Cognition/drug effects; Diet, Western/adverse effects; Disease Models, Animal; Hippocampus/drug effects; Hippocampus/pathology; Humans; Inflammasomes/drug effects; Inflammasomes/metabolism; Inflammation/genetics; Inflammation/pathology; Insulin Resistance/genetics; Interleukin-18/genetics; Lipopolysaccharides/pharmacology; Microglia/drug effects; Microglia/pathology; Peptide Fragments/genetics; Pyroptosis/drug effects; Rats; Receptors, Serotonin, 5-HT3/genetics; Risk Factors; Spatial Memory/drug effects

Key words

5-HT3 receptor blocker; caspase-1/IL-1ß/IL-18; inflammasome; microglia; pyroptosis; α7AChR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aconitine / Alzheimer Disease / Palonosetron / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Egypt Country of publication: Switzerland

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