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Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy.
Korolkov, Ilya V; Zibert, Alexandr V; Lissovskaya, Lana I; Ludzik, K; Anisovich, M; Kozlovskiy, Artem L; Shumskaya, A E; Vasilyeva, M; Shlimas, Dmitriy I; Jazdzewska, Monika; Marciniak, Beata; Kontek, Renata; Chudoba, Dorota; Zdorovets, Maxim V.
Affiliation
  • Korolkov IV; The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty 050032, Kazakhstan.
  • Zibert AV; Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan 010008, Kazakhstan.
  • Lissovskaya LI; The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty 050032, Kazakhstan.
  • Ludzik K; Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan 010008, Kazakhstan.
  • Anisovich M; The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty 050032, Kazakhstan.
  • Kozlovskiy AL; Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan 010008, Kazakhstan.
  • Shumskaya AE; Department of Physical Chemistry, University of Lodz, 90-236 Lodz, Poland.
  • Vasilyeva M; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna 141980, Russia.
  • Shlimas DI; Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, 220012 Minsk, Belarus.
  • Jazdzewska M; The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty 050032, Kazakhstan.
  • Marciniak B; Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan 010008, Kazakhstan.
  • Kontek R; The Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Chudoba D; Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, 220012 Minsk, Belarus.
  • Zdorovets MV; The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty 050032, Kazakhstan.
Int J Mol Sci ; 22(16)2021 Aug 13.
Article in En | MEDLINE | ID: mdl-34445393
In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for further immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet-visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, morphology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron / Boron Neutron Capture Therapy / Gadolinium Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Kazakhstan Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron / Boron Neutron Capture Therapy / Gadolinium Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Kazakhstan Country of publication: Switzerland