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APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aß generation.
Lee, Se-In; Jeong, Woojin; Lim, Heejin; Cho, Sukhee; Lee, Hyein; Jang, Yonghee; Cho, Joonho; Bae, Simsung; Lin, Yuan-Ta; Tsai, Li-Huei; Moon, Dae Won; Seo, Jinsoo.
Affiliation
  • Lee SI; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Jeong W; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Lim H; Department of New Biology, DGIST, Daegu 42988, South Korea.
  • Cho S; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Lee H; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Jang Y; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Cho J; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Bae S; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Lin YT; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Tsai LH; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Moon DW; Department of New Biology, DGIST, Daegu 42988, South Korea.
  • Seo J; Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea. Electronic address: jsseo@dgist.ac.kr.
Stem Cell Reports ; 16(9): 2128-2137, 2021 09 14.
Article in En | MEDLINE | ID: mdl-34450034
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Cholesterol / Amyloid beta-Peptides / Membrane Microdomains / Apolipoprotein E4 / Neurons Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article Affiliation country: South Korea Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Cholesterol / Amyloid beta-Peptides / Membrane Microdomains / Apolipoprotein E4 / Neurons Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article Affiliation country: South Korea Country of publication: United States