New strategies for targeting kinase networks in cancer.

Yesilkanal, Ali E; Johnson, Gary L; Ramos, Alexandre F; Rosner, Marsha Rich

Yesilkanal, Ali E; Johnson, Gary L; Ramos, Alexandre F; Rosner, Marsha Rich.

Affiliation

Yesilkanal AE; Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA. Electronic address: aeyesilkanal@gmail.com.
Johnson GL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ramos AF; Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina and Escola de Artes, Ciências e Humanidades, University of São Paulo, Brazil.
Rosner MR; Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA. Electronic address: m-rosner@uchicago.edu.

J Biol Chem ; 297(4): 101128, 2021 10.

Article in En | MEDLINE | ID: mdl-34461089

Subject(s)

Imatinib Mesylate/therapeutic use; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors/therapeutic use; Protein Kinases/metabolism; Animals; Humans; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/metabolism; Neoplasms/drug therapy; Neoplasms/enzymology

Key words

cancer therapy; cell signaling; combination therapy; drug resistance; inhibitor; kinase network; mathematical modeling; mitogen-activated protein kinase (MAPK); receptor tyrosine kinases; targeted therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Protein Kinase Inhibitors / Imatinib Mesylate / Neoplasm Proteins / Neoplasms Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Country of publication: United States

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