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N-Acetylcysteine prevents amyloid-ß secretion in neurons derived from human pluripotent stem cells with trisomy 21.
Toshikawa, Hiromitsu; Ikenaka, Akihiro; Li, Li; Nishinaka-Arai, Yoko; Niwa, Akira; Ashida, Akira; Kazuki, Yasuhiro; Nakahata, Tatsutoshi; Tamai, Hiroshi; Russell, David W; Saito, Megumu K.
Affiliation
  • Toshikawa H; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Ikenaka A; Osaka Medical and Pharmaceutical University, Takatsuki, 5690801, Japan.
  • Li L; Social Welfare Organization "SAISEIKAI" Imperial Gift Foundation Inc., Saiseikai Suita Hospital, Suita, 5640013, Japan.
  • Nishinaka-Arai Y; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Niwa A; Division of Hematology, School of Medicine, University of Washington, Seattle, WA, 98195, USA.
  • Ashida A; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Kazuki Y; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 6068507, Japan.
  • Nakahata T; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Tamai H; Osaka Medical and Pharmaceutical University, Takatsuki, 5690801, Japan.
  • Russell DW; Chromosome Engineering Research Center, Tottori University, Tottori, Japan.
  • Saito MK; Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Tottori, Japan.
Sci Rep ; 11(1): 17377, 2021 08 30.
Article in En | MEDLINE | ID: mdl-34462463
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Down-Regulation / Amyloid beta-Peptides / Down Syndrome / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Down-Regulation / Amyloid beta-Peptides / Down Syndrome / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Japan Country of publication: United kingdom