How to generate graded spinal cord injuries in swine - tools and procedures.
Dis Model Mech
; 14(8)2021 08 01.
Article
in En
| MEDLINE
| ID: mdl-34464444
ABSTRACT
Spinal cord injury (SCI) is a medically, psychologically and socially disabling condition. A large body of our knowledge on the basic mechanisms of SCI has been gathered in rodents. For preclinical validation of promising therapies, the use of animal models that are closer to humans has several advantages. This has promoted the more-intensive development of large-animal models for SCI during the past decade. We recently developed a multimodal SCI apparatus for large animals that generated biomechanically reproducible impacts in vivo. It is composed of a spring-load impactor and support systems for the spinal cord and the vertebral column. We now present the functional outcome of farm pigs and minipigs injured with different lesion strengths. There was a correlation between the biomechanical characteristics of the impact, the functional outcome and the tissue damage observed several weeks after injury. We also provide a detailed description of the procedure to generate such a SCI in both farm pigs and minipigs, in the hope to ease the adoption of the swine model by other research groups.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord Injuries
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Dis Model Mech
Journal subject:
MEDICINA
Year:
2021
Document type:
Article
Affiliation country:
Norway