Your browser doesn't support javascript.
loading
Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center.
Zhang, Yumeng; Seminario-Vidal, Lucia; Varnadoe, Christa; Lu, Yuanyuan; Dong, Ning; Salamanca, Christopher; Whiddon, Shannen; Bennett, Janice; Hargis, Rebecca; Liu, Hien; Montejo, Michael; Hussaini, Mohammad; Harro, Carly; Messina, Jane; Benson, Kaaron; Pinilla-Ibarz, Javier; Conejo-Garcia, Jose; Sokol, Lubomir.
Affiliation
  • Zhang Y; Department of Medicine, University of South Florida& H. Lee Moffitt Cancer Center and Research Institute, FL, USA, USA.
  • Seminario-Vidal L; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Varnadoe C; Yale School of Nursing, New Haven, CT, USA.
  • Lu Y; College of Public Health, University of South Florida, Tampa, FL, USA.
  • Dong N; Department of Medicine, University of South Florida& H. Lee Moffitt Cancer Center and Research Institute, FL, USA, USA.
  • Salamanca C; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Whiddon S; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Bennett J; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Hargis R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Liu H; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Montejo M; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Hussaini M; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Harro C; Department of Cancer Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Messina J; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Benson K; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Pinilla-Ibarz J; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Conejo-Garcia J; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Sokol L; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Leuk Lymphoma ; 63(1): 109-116, 2022 01.
Article in En | MEDLINE | ID: mdl-34467825
ABSTRACT
Sézary syndrome (SS) is a rare and aggressive leukemic variant of cutaneous T-cell lymphoma, with a median overall survival (OS) rate of 2-4 years. Few studies have described the clinical outcome of SS patients since 2012. We retrospectively analyzed 70 patients diagnosed with SS treated at a high-volume tertiary cancer center between 2000 and 2018. Overall survival at 1 and 5 years was 84.1% and 50.7%, respectively. Univariate analyses identified older age (>65 years) and male sex as poor prognostic factors. Five patients presented with circulating large granular lymphocytic proliferation and had a favorable prognosis. Targeted therapies were effective in treating refractory/relapsed SS patients with a durable response. Therapeutic advancements and the comprehensive treatments used in a multidisciplinary clinic improved OS rates.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Lymphoma, T-Cell, Cutaneous / Mycosis Fungoides / Sezary Syndrome Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans / Male Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Lymphoma, T-Cell, Cutaneous / Mycosis Fungoides / Sezary Syndrome Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans / Male Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: United States