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Fluorescence In Situ Hybridization for the Origin of De Novo Renal Cell Carcinoma in a Kidney Allograft: A Case Report.
Kijima, Yu; Iida, Shoichi; Nozaki, Taiji; Sekido, Eri; Toguchi, Makoto; Horiuchi, Toshihide; Omoto, Kazuya; Inui, Masashi; Toma, Hiroshi; Shimizu, Tomokazu.
Affiliation
  • Kijima Y; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: meyu10033@gmail.com.
  • Iida S; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Nozaki T; Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan.
  • Sekido E; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Toguchi M; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Horiuchi T; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Omoto K; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Inui M; Department of Urology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
  • Toma H; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
  • Shimizu T; Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Transplant Proc ; 53(8): 2552-2555, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34474910
ABSTRACT

BACKGROUND:

We present a rare case of de novo renal cell carcinoma that developed in an allograft kidney 14 years after transplantation. CASE REPORT A 39-year-old man underwent living donor kidney transplantation from his mother. After 14 years, routine screening ultrasonography revealed a solid mass of 30-mm diameter in the kidney allograft. Partial nephrectomy was performed by clamping the renal artery under in situ cooling. Tissue histology revealed clear cell carcinoma with negative surgical margins. We explored the tumor's genetic origin using fluorescence in situ hybridization to analyze the X and Y chromosomes of the tumor cells. Postoperative hemodialysis was avoided, and the patient's serum creatinine level remained stable.

CONCLUSIONS:

Fluorescence in situ hybridization clearly indicated that the tumor originated from the donor and that the tumor vasculature originated from the recipient. The patient recovered well and remains without any tumor recurrence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Kidney Transplantation / Kidney Neoplasms Type of study: Etiology_studies Limits: Adult / Humans / Male Language: En Journal: Transplant Proc Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Kidney Transplantation / Kidney Neoplasms Type of study: Etiology_studies Limits: Adult / Humans / Male Language: En Journal: Transplant Proc Year: 2021 Document type: Article