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An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury.
Xiao, Rong-Rong; Lv, Tian; Tu, Xia; Li, Peiwen; Wang, Tiantian; Dong, Haiheng; Tu, Pengfei; Ai, Xiaoni.
Affiliation
  • Xiao RR; R&D Department, Beijing Daxiang Biotech, Beijing, China.
  • Lv T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
  • Tu X; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
  • Li P; R&D Department, Beijing Daxiang Biotech, Beijing, China.
  • Wang T; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
  • Dong H; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
  • Tu P; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
  • Ai X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Biotechnol Bioeng ; 118(12): 4687-4698, 2021 12.
Article in En | MEDLINE | ID: mdl-34478150
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Drug Evaluation, Preclinical / Chemical and Drug Induced Liver Injury / Lab-On-A-Chip Devices / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biotechnol Bioeng Year: 2021 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Drug Evaluation, Preclinical / Chemical and Drug Induced Liver Injury / Lab-On-A-Chip Devices / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biotechnol Bioeng Year: 2021 Document type: Article Affiliation country: China Country of publication: United States