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C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
Kalcic, Filip; Frydrych, Jan; Dolezelová, Eva; Slapnicková, Martina; Pachl, Petr; Slavetínská, Lenka Postová; Dracínský, Martin; Hocková, Dana; Zíková, Alena; Janeba, Zlatko.
Affiliation
  • Kalcic F; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43, Prague 2, Czech Republic.
  • Frydrych J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
  • Dolezelová E; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branisovská 31, Ceské Budejovice, 37005, Czech Republic.
  • Slapnicková M; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branisovská 31, Ceské Budejovice, 37005, Czech Republic.
  • Pachl P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
  • Slavetínská LP; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
  • Dracínský M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
  • Hocková D; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
  • Zíková A; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branisovská 31, Ceské Budejovice, 37005, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 31, Ceské Budejovice, 37005, Czech Republic. Electronic address: azikova@paru.cas.cz.
  • Janeba Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic. Electronic address: janeba@uochb.cas.cz.
Eur J Med Chem ; 225: 113798, 2021 Dec 05.
Article in En | MEDLINE | ID: mdl-34482272
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma brucei brucei / Adenine Phosphoribosyltransferase / Adenosine Monophosphate / Enzyme Inhibitors / Antiprotozoal Agents / Nucleosides Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Czech Republic Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma brucei brucei / Adenine Phosphoribosyltransferase / Adenosine Monophosphate / Enzyme Inhibitors / Antiprotozoal Agents / Nucleosides Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Czech Republic Country of publication: France