Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat.
Pharmacol Res Commun
; 19(12): 901-12, 1987 Dec.
Article
in En
| MEDLINE
| ID: mdl-3448611
ABSTRACT
The acquisition of a passive avoidance conditioned response was disrupted in the rat by electroconvulsive shock (ECS) and scopolamine administration. D,L-pyroglutamic acid (D,L-PCA) 500 and 1000 mg/kg, administered as arginine salt 120 min before the retest, prevented both the ECS and scopolamine-induced amnesia. Arginine alone was ineffective. Scopolamine brought about a 52 and 39% decrease, respectively, in cortical and hippocampal acetylcholine (ACh) levels, measured by means of a gas-chromatographic method. D,L-PCA 500 and 1000 mg/kg also prevented the decrease in brain ACh level. When the two isomers were studied separately, D-PCA was more effective than L-PCA and antagonized scopolamine-induced amnesia at the doses of 250 and 500 mg/kg. In conclusion, D,L-PCA is active on cortical and hippocampal cholinergic mechanisms and, like other 2-oxopyrrolidone derivatives, shows cognition-enhancing properties.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrrolidinones
/
Pyrrolidonecarboxylic Acid
/
Scopolamine
/
Brain Chemistry
/
Acetylcholine
/
Electroshock
/
Memory
Limits:
Animals
Language:
En
Journal:
Pharmacol Res Commun
Year:
1987
Document type:
Article
Affiliation country:
Italy