Dermal exposure to cobalt studied <i>in vitro</i> in keratinocytes - effects of cobalt exposure on inflammasome activated cytokines, and mRNA response.

Klasson, Maria; Lindberg, Magnus; Westberg, Håkan; Bryngelsson, Ing-Liss; Tuerxun, Kedeye; Persson, Alexander; Särndahl, Eva

Dermal exposure to cobalt studied in vitro in keratinocytes - effects of cobalt exposure on inflammasome activated cytokines, and mRNA response.

Klasson, Maria; Lindberg, Magnus; Westberg, Håkan; Bryngelsson, Ing-Liss; Tuerxun, Kedeye; Persson, Alexander; Särndahl, Eva.

Affiliation

Klasson M; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Lindberg M; Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Westberg H; Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Bryngelsson IL; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Tuerxun K; Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Persson A; Department of Dermatology, University Hospital Örebro, Örebro, Sweden.
Särndahl E; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Biomarkers ; 26(8): 674-684, 2021 Dec.

Article in En | MEDLINE | ID: mdl-34496682

Subject(s)

Cobalt/pharmacology; Cytokines/genetics; Inflammasomes/drug effects; Keratinocytes/drug effects; RNA, Messenger/genetics; Skin/drug effects; Caspase 1/genetics; Caspase 1/metabolism; Cell Line; Cytokines/metabolism; Dose-Response Relationship, Drug; Gene Expression/drug effects; Humans; Inflammasomes/genetics; Inflammasomes/metabolism; Interleukin-18/genetics; Interleukin-18/metabolism; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Keratinocytes/cytology; Keratinocytes/metabolism; Linear Models; RNA, Messenger/metabolism; Skin/cytology; Skin/metabolism; Time Factors

Key words

CoCl2; HaCaT; IL-18; IL-1ß; NLRP3 inflammasome; caspase-1; skin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / RNA, Messenger / Keratinocytes / Cytokines / Cobalt / Inflammasomes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biomarkers Journal subject: BIOQUIMICA Year: 2021 Document type: Article Affiliation country: Sweden Country of publication: United kingdom

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