Impact of Amyloid-ß on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease.

Donner, Lili; Feige, Tobias; Freiburg, Carolin; Toska, Laura Mara; Reichert, Andreas S; Chatterjee, Madhumita; Elvers, Margitta

Donner, Lili; Feige, Tobias; Freiburg, Carolin; Toska, Laura Mara; Reichert, Andreas S; Chatterjee, Madhumita; Elvers, Margitta.

Affiliation

Donner L; Department of Vascular and Endovascular Surgery, Experimental Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Feige T; Department of Vascular and Endovascular Surgery, Experimental Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Freiburg C; Department of Vascular and Endovascular Surgery, Experimental Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Toska LM; Department of Vascular and Endovascular Surgery, Experimental Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Reichert AS; Institute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Chatterjee M; Department of Cardiology and Angiology, Universitätsklinikum Tübingen, Medizinische Klinik III, 72076 Tübingen, Germany.
Elvers M; Department of Vascular and Endovascular Surgery, Experimental Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.

Int J Mol Sci ; 22(17)2021 Sep 06.

Article in En | MEDLINE | ID: mdl-34502546

Subject(s)

Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid/metabolism; Blood Platelets/metabolism; Mitochondria/metabolism; Protein Aggregation, Pathological/metabolism; Alzheimer Disease/genetics; Amyloid beta-Peptides/pharmacology; Animals; Blood Platelets/cytology; Blood Platelets/drug effects; Cells, Cultured; Humans; Integrins/metabolism; Membrane Potential, Mitochondrial/genetics; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria/drug effects; Mitochondrial Proteins/metabolism; Oxygen Consumption/drug effects; Platelet Activation/drug effects; Platelet Function Tests/methods; Reactive Oxygen Species/metabolism

Key words

Alzheimer's disease; Aß aggregation; GPVI; ROS; cerebral amyloid angiopathy; integrin; mitochondria dysfunction; platelets

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Amyloid beta-Peptides / Alzheimer Disease / Protein Aggregation, Pathological / Amyloid / Mitochondria Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Germany Country of publication: Switzerland

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