All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity.
Proc Natl Acad Sci U S A
; 118(37)2021 09 14.
Article
in En
| MEDLINE
| ID: mdl-34508001
Disinhibition is an obligatory initial step in the remodeling of cortical circuits by sensory experience. Our investigation on disinhibitory mechanisms in the classical model of ocular dominance plasticity uncovered an unexpected form of experience-dependent circuit plasticity. In the layer 2/3 of mouse visual cortex, monocular deprivation triggers a complete, "all-or-none," elimination of connections from pyramidal cells onto nearby parvalbumin-positive interneurons (PyrâPV). This binary form of circuit plasticity is unique, as it is transient, local, and discrete. It lasts only 1 d, and it does not manifest as widespread changes in synaptic strength; rather, only about half of local connections are lost, and the remaining ones are not affected in strength. Mechanistically, the deprivation-induced loss of PyrâPV is contingent on a reduction of the protein neuropentraxin2. Functionally, the loss of PyrâPV is absolutely necessary for ocular dominance plasticity, a canonical model of deprivation-induced model of cortical remodeling. We surmise, therefore, that this all-or-none loss of local PyrâPV circuitry gates experience-dependent cortical plasticity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parvalbumins
/
Visual Cortex
/
Pyramidal Cells
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Dominance, Ocular
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Interneurons
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Neural Inhibition
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Neuronal Plasticity
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2021
Document type:
Article
Country of publication:
United States