Role of the Extracellular Matrix in Alzheimer's Disease.
Front Aging Neurosci
; 13: 707466, 2021.
Article
in En
| MEDLINE
| ID: mdl-34512308
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological characteristics, whose etiology and pathogenesis are still unclear. Over the past few decades, the role of the extracellular matrix (ECM) has gained importance in neurodegenerative disease. In this review, we describe the role of the ECM in AD, focusing on the aspects of synaptic transmission, amyloid-ß-plaque generation and degradation, Tau-protein production, oxidative-stress response, and inflammatory response. The function of ECM in the pathological process of AD will inform future research on the etiology and pathogenesis of AD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Aging Neurosci
Year:
2021
Document type:
Article
Affiliation country:
China