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The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.
Gandelman, Mandi; Dansithong, Warunee; Kales, Stephen C; Paul, Sharan; Maag, Gentrie; Aoyama, Erika; Zakharov, Alexey; Rai, Ganesha; Dexheimer, Thomas; Whitehill, Brooke M; Sun, Hongmao; Jadhav, Ajit; Simeonov, Anton; Henderson, Mark J; Huynh, Duong P; Pulst, Stefan M; Scoles, Daniel R.
Affiliation
  • Gandelman M; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Dansithong W; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Kales SC; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Paul S; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Maag G; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Aoyama E; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Zakharov A; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Rai G; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Dexheimer T; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA.
  • Whitehill BM; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Sun H; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Jadhav A; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Simeonov A; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Henderson MJ; Department of Neurology, National Center for Advancing Translational Sciences (NCATS), Rockville, Maryland, USA.
  • Huynh DP; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Pulst SM; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Scoles DR; Department of Neurology, University of Utah, Salt Lake City, Utah, USA. Electronic address: Daniel.Scoles@hsc.utah.edu.
J Biol Chem ; 297(4): 101191, 2021 10.
Article in En | MEDLINE | ID: mdl-34520759
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Gene Expression Regulation / Proto-Oncogene Proteins c-akt / Alpha-Synuclein / Endoplasmic Reticulum Stress / Indazoles / Indoles Limits: Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Gene Expression Regulation / Proto-Oncogene Proteins c-akt / Alpha-Synuclein / Endoplasmic Reticulum Stress / Indazoles / Indoles Limits: Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States