Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.

Peshenko, Igor V; Olshevskaya, Elena V; Dizhoor, Alexander M

Peshenko, Igor V; Olshevskaya, Elena V; Dizhoor, Alexander M.

Affiliation

Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Olshevskaya EV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA. Electronic address: adizhoor@salus.edu.

J Biol Chem ; 297(4): 101201, 2021 10.

Article in En | MEDLINE | ID: mdl-34537244

Subject(s)

Guanylate Cyclase/metabolism; Nuclear Proteins/metabolism; Photoreceptor Cells, Vertebrate/metabolism; Receptors, Cell Surface/metabolism; Animals; Guanylate Cyclase/genetics; Guanylate Cyclase-Activating Proteins/genetics; Guanylate Cyclase-Activating Proteins/metabolism; HEK293 Cells; Humans; Isoenzymes/genetics; Isoenzymes/metabolism; Mice; Mice, Knockout; Mutation; Nuclear Proteins/genetics; Receptors, Cell Surface/genetics; Retinitis Pigmentosa/genetics; Retinitis Pigmentosa/metabolism

Key words

GCAP; GUCY2D; RD3; RetGC; calcium-binding proteins; cyclic GMP; eye; guanylate cyclase (guanylyl cyclase); photoreceptor; retinal degeneration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Receptors, Cell Surface / Photoreceptor Cells, Vertebrate / Guanylate Cyclase Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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