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Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
Hanada, Keita; Kawada, Kenji; Nishikawa, Gen; Toda, Kosuke; Maekawa, Hisatsugu; Nishikawa, Yasuyo; Masui, Hideyuki; Hirata, Wataru; Okamoto, Michio; Kiyasu, Yoshiyuki; Honma, Shusaku; Ogawa, Ryotaro; Mizuno, Rei; Itatani, Yoshiro; Miyoshi, Hiroyuki; Sasazuki, Takehiko; Shirasawa, Senji; Taketo, M Mark; Obama, Kazutaka; Sakai, Yoshiharu.
Affiliation
  • Hanada K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kawada K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: kkawada@kuhp.kyoto-u.ac.jp.
  • Nishikawa G; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Toda K; Department of Surgery, Otsu City Hospital, Otsu, Japan.
  • Maekawa H; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nishikawa Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Masui H; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Hirata W; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Okamoto M; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kiyasu Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Honma S; Department of Surgery, Kobe City Medical Center West Hospital, Kobe, Japan.
  • Ogawa R; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Mizuno R; Department of Surgery, Uji Tokushukai Medical Center, Kyoto, Japan.
  • Itatani Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Miyoshi H; Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan.
  • Sasazuki T; Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
  • Shirasawa S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
  • Taketo MM; Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan.
  • Obama K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Sakai Y; Department of Surgery, Osaka Red Cross Hospital, Osaka, Japan.
Cancer Lett ; 522: 129-141, 2021 12 01.
Article in En | MEDLINE | ID: mdl-34543685
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pinocytosis / Aspartate-Ammonia Ligase / Colorectal Neoplasms / Proto-Oncogene Proteins p21(ras) Limits: Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pinocytosis / Aspartate-Ammonia Ligase / Colorectal Neoplasms / Proto-Oncogene Proteins p21(ras) Limits: Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Ireland