Haemoglobin drives inflammation and initiates antigen spread and nephritis in lupus.

Sharma, Hritika; Bose, Anjali; Sachdeva, Ruchi; Malik, Monika; Kumar, Uma; Pal, Rahul

Sharma, Hritika; Bose, Anjali; Sachdeva, Ruchi; Malik, Monika; Kumar, Uma; Pal, Rahul.

Affiliation

Sharma H; Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.
Bose A; Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.
Sachdeva R; Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.
Malik M; Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.
Kumar U; Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India.
Pal R; Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.

Immunology ; 165(1): 122-140, 2022 01.

Article in En | MEDLINE | ID: mdl-34549818

Subject(s)

Autoantigens/immunology; Hemoglobins/metabolism; Lupus Erythematosus, Systemic/complications; Lupus Erythematosus, Systemic/immunology; Lupus Nephritis/etiology; Lupus Nephritis/metabolism; Animals; Apoptosis/genetics; Apoptosis/immunology; Autoantibodies/immunology; Biomarkers; Cytokines/metabolism; Dendritic Cells/drug effects; Dendritic Cells/immunology; Dendritic Cells/metabolism; Disease Susceptibility; Humans; Imidazoles/pharmacology; Leukocytes, Mononuclear/immunology; Leukocytes, Mononuclear/metabolism; Lipopolysaccharides/immunology; Lupus Nephritis/pathology; Lymphocyte Activation/immunology; Lymphocyte Subsets/drug effects; Lymphocyte Subsets/immunology; Lymphocyte Subsets/metabolism; Mice; Protein Binding; Signal Transduction; Spleen/immunology; Spleen/metabolism

Key words

antigen spreading; apoptosis; autoimmunity; haemoglobin; systemic lupus erythematosus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantigens / Lupus Nephritis / Hemoglobins / Lupus Erythematosus, Systemic Limits: Animals / Humans Language: En Journal: Immunology Year: 2022 Document type: Article Affiliation country: India Country of publication: United kingdom

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