New Immunotherapeutic Approaches for Glioblastoma.
J Immunol Res
; 2021: 3412906, 2021.
Article
in En
| MEDLINE
| ID: mdl-34557553
ABSTRACT
Glioblastoma (GBM) is the most common primary malignant brain tumor with a high mortality rate. The current treatment consists of surgical resection, radiation, and chemotherapy; however, the median survival rate is only 12-18 months despite these alternatives, highlighting the urgent need to find new strategies. The heterogeneity of GBM makes this tumor difficult to treat, and the immunotherapies result in an attractive approach to modulate the antitumoral immune responses favoring the tumor eradication. The immunotherapies for GMB including monoclonal antibodies, checkpoint inhibitors, vaccines, and oncolytic viruses, among others, have shown favorable results alone or as a multimodal treatment. In this review, we summarize and discuss promising immunotherapies for GBM currently under preclinical investigation as well as in clinical trials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Glioblastoma
/
Immunotherapy
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Immunol Res
Year:
2021
Document type:
Article
Affiliation country:
Mexico
Publication country:
EG
/
EGIPTO
/
EGITO
/
EGYPT