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Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies.
Yaman, Samet; Basci, Semih; Turan, Gökhan; Ulu, Bahar Uncu; Yigenoglu, Tugçe Nur; Dal, Mehmet Sinan; Kizil Çakar, Merih; Altuntas, Fevzi.
Affiliation
  • Yaman S; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey. Electronic address: dr.semihbasci@gmail.com.
  • Basci S; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Turan G; Department of Internal Medicine, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Ulu BU; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Yigenoglu TN; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Dal MS; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Kizil Çakar M; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Altuntas F; Department of Hematology and Bone Marrow Transplantation Center, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Clin Lymphoma Myeloma Leuk ; 22(2): e71-e76, 2022 02.
Article in En | MEDLINE | ID: mdl-34565690
INTRODUCTION: Tumor lysis syndrome (TLS) is a commonly observed oncological emergency that requires prompt diagnosis and treatment. Rasburicase is a recombinant urate oxidase endorsed in TLS for the treatment of hyperuricemia. The effect of single-dose 7.5 mg rasburicase at longer follow-ups was not widely investigated. PATIENTS AND METHODS: Eighty-two patients included in the study with clinical TLS and laboratory TLS. The primary endpoint was the normalization of uric acid (<6mg/dL) within 24 hours of rasburicase administration, which was described as treatment success. The secondary endpoint was defined as having sustained response at the first week. The third endpoint was defined as the reaching the baseline renal function before TLS. RESULTS: We found that the use of a 7.5 mg dose of rasburicase controlled uric acid in 74 of 82 (90,2%) patients at the 24th hour. In the first week, uric acid remained at normal levels in 69 of 82 (84,1%) patients. At 24 hours, the TLS risk group was the only predictor for failing uric acid normalization; at the end of the first week, no predictive factor was identified for failing uric acid normalization. CONCLUSION: Rasburicase at 7.5 mg dose is an important agent for controlling laboratory and clinical TLS at 24 hours and extending its effect to the first week.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Lysis Syndrome / Hematologic Neoplasms / Hyperuricemia Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Clin Lymphoma Myeloma Leuk Journal subject: NEOPLASIAS Year: 2022 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Lysis Syndrome / Hematologic Neoplasms / Hyperuricemia Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Clin Lymphoma Myeloma Leuk Journal subject: NEOPLASIAS Year: 2022 Document type: Article Country of publication: United States