Microwave-Assisted, One-Pot Synthesis of Doxycycline under Heterogeneous Catalysis in Water.
Antibiotics (Basel)
; 10(9)2021 Sep 08.
Article
in En
| MEDLINE
| ID: mdl-34572666
ABSTRACT
The selective synthesis of active pharmaceutical molecules is a challenging issue, particularly when attempting to make the reactions even more sustainable. The present work focuses on the microwave-assisted hydrogenolysis of oxytetracycline to selectively produce α-doxycycline. Although the combination of microwave irradiation and a heterogeneous rhodium catalyst provided good conversions, the selective synthesis of active α-doxycycline was only achieved when an oxytetracycline-cyclodextrin complex was used as the starting material, giving the desired product at 34.0% yield in a one-step reaction under very mild conditions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Antibiotics (Basel)
Year:
2021
Document type:
Article
Affiliation country:
Italy