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Synthesis and Study of Antifungal Properties of New Cationic Beta-Glucan Derivatives.
Kaminski, Kamil; Skora, Magdalena; Krzysciak, Pawel; Staczek, Sylwia; Zdybicka-Barabas, Agnieszka; Cytrynska, Malgorzata.
Affiliation
  • Kaminski K; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2 St., 30-387 Krakow, Poland.
  • Skora M; Department of Infections Control and Mycology, Chair of Microbiology, Jagiellonian University Medical College, Czysta 18 St., 31-121 Krakow, Poland.
  • Krzysciak P; Department of Infections Control and Mycology, Chair of Microbiology, Jagiellonian University Medical College, Czysta 18 St., 31-121 Krakow, Poland.
  • Staczek S; Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19 St., 20-033 Lublin, Poland.
  • Zdybicka-Barabas A; Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19 St., 20-033 Lublin, Poland.
  • Cytrynska M; Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19 St., 20-033 Lublin, Poland.
Pharmaceuticals (Basel) ; 14(9)2021 Aug 24.
Article in En | MEDLINE | ID: mdl-34577538
The interaction of positively charged polymers (polycations) with a biological membrane is considered to be the cause of the frequently observed toxicity of these macromolecules. If it is possible to obtain polymers with a predominantly negative effect on bacterial and fungal cells, such systems would have great potential in the treatment of infectious diseases, especially now when reports indicate the growing risk of fungal co-infections in COVID-19 patients. We describe in this article cationic derivatives of natural beta-glucan polymers obtained by reacting the polysaccharide isolated from Saccharomyces boulardii (SB) and Cetraria islandica (CI) with glycidyl trimethyl ammonium chloride (GTMAC). Two synthesis strategies were applied to optimize the product yield. Fungal diseases particularly affect low-income countries, hence the emphasis on the simplicity of the synthesis of such drugs so they can be produced without outside help. The three structures obtained showed selective anti-mycotic properties (against, i.e., Scopulariopsis brevicaulis, Aspergillus brasiliensis, and Fusarium solani), and their toxicity established using fibroblast 3T3-L1 cell line was negligible in a wide range of concentrations. For one of the polymers (SB derivative), using in vivo model of Aspergillus brasiliensis infection in Galleria mellonella insect model, we confirmed the promising results obtained in the preliminary study.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceuticals (Basel) Year: 2021 Document type: Article Affiliation country: Poland Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceuticals (Basel) Year: 2021 Document type: Article Affiliation country: Poland Country of publication: Switzerland