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Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase.
Timoshina, Olga Yu; Shneider, Mikhail M; Evseev, Peter V; Shchurova, Anastasia S; Shelenkov, Andrey A; Mikhaylova, Yulia V; Sokolova, Olga S; Kasimova, Anastasia A; Arbatsky, Nikolay P; Dmitrenok, Andrey S; Knirel, Yuriy A; Miroshnikov, Konstantin A; Popova, Anastasia V.
Affiliation
  • Timoshina OY; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
  • Shneider MM; Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia.
  • Evseev PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
  • Shchurova AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
  • Shelenkov AA; Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, Dolgoprudny, 141700 Moscow, Russia.
  • Mikhaylova YV; Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia.
  • Sokolova OS; Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia.
  • Kasimova AA; Biology Department, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.
  • Arbatsky NP; Biology Department, Shenzhen MSU-BIT University, 1 International University Park Road, Longgang District, Shenzhen 518172, China.
  • Dmitrenok AS; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
  • Knirel YA; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
  • Miroshnikov KA; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
  • Popova AV; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
Viruses ; 13(9)2021 08 26.
Article in En | MEDLINE | ID: mdl-34578271
ABSTRACT
Acinetobacter baumannii appears to be one of the most crucial nosocomial pathogens. A possible component of antimicrobial therapy for infections caused by extremely drug-resistant A. baumannii strains may be specific lytic bacteriophages or phage-derived enzymes. In the present study, we observe the biological features, genomic organization, and phage-host interaction strategy of novel virulent bacteriophage Aristophanes isolated on A. baumannii strain having K26 capsular polysaccharide structure. According to phylogenetic analysis phage Aristophanes can be classified as a representative of a new distinct genus of the subfamily Beijerinckvirinae of the family Autographiviridae. This is the first reported A. baumannii phage carrying tailspike deacetylase, which caused O-acetylation of one of the K26 sugar residues.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Viral Proteins / Acinetobacter baumannii / Amidohydrolases Language: En Journal: Viruses Year: 2021 Document type: Article Affiliation country: RUSSIA
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Viral Proteins / Acinetobacter baumannii / Amidohydrolases Language: En Journal: Viruses Year: 2021 Document type: Article Affiliation country: RUSSIA