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In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Carlet, Michela; Völse, Kerstin; Vergalli, Jenny; Becker, Martin; Herold, Tobias; Arner, Anja; Senft, Daniela; Jurinovic, Vindi; Liu, Wen-Hsin; Gao, Yuqiao; Dill, Veronika; Fehse, Boris; Baldus, Claudia D; Bastian, Lorenz; Lenk, Lennart; Schewe, Denis M; Bagnoli, Johannes W; Vick, Binje; Schmid, Jan Philipp; Wilhelm, Alexander; Marschalek, Rolf; Jost, Philipp J; Miething, Cornelius; Riecken, Kristoffer; Schmidt-Supprian, Marc; Binder, Vera; Jeremias, Irmela.
Affiliation
  • Carlet M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Völse K; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Vergalli J; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Becker M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Arner A; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Senft D; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.
  • Jurinovic V; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany.
  • Liu WH; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Gao Y; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Dill V; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Fehse B; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany.
  • Baldus CD; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Bastian L; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Lenk L; Clinic and Policlinic for Internal Medicine III, Technical University of Munich, School of Medicine, Munich, Germany.
  • Schewe DM; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bagnoli JW; Internal Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Vick B; Internal Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Schmid JP; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
  • Wilhelm A; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
  • Marschalek R; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Munich, Germany.
  • Jost PJ; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Miething C; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.
  • Riecken K; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Schmidt-Supprian M; Institute of Pharmaceutical Biology, Diagnosic Center of Acute Leukemias (DCAL), Goethe-University, Frankfurt/Main, Germany.
  • Binder V; Institute of Pharmaceutical Biology, Diagnosic Center of Acute Leukemias (DCAL), Goethe-University, Frankfurt/Main, Germany.
  • Jeremias I; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.
Nat Commun ; 12(1): 5655, 2021 09 27.
Article in En | MEDLINE | ID: mdl-34580292
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Biomarkers, Tumor / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Reverse Genetics / Antineoplastic Agents Type of study: Observational_studies / Prognostic_studies Limits: Adult / Animals / Child / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Biomarkers, Tumor / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Reverse Genetics / Antineoplastic Agents Type of study: Observational_studies / Prognostic_studies Limits: Adult / Animals / Child / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom