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Dose-dependent inactivation of airway tryptase with a novel dissociating anti-tryptase antibody (MTPS9579A) in healthy participants: A randomized trial.
Rymut, Sharon M; Sukumaran, Siddharth; Sperinde, Gizette; Bremer, Meire; Galanter, Joshua; Yoshida, Kenta; Smith, Jordan; Banerjee, Prajna; Sverkos, Viyia; Cai, Fang; Steffen, Verena; Henderson, Lindsay M; Rhee, Horace; Belloni, Paula N; Lin, Joseph H; Staton, Tracy L.
Affiliation
  • Rymut SM; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
  • Sukumaran S; Department of Preclinical and Translational PKPD, Genentech, Inc., South San Francisco, California, USA.
  • Sperinde G; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA.
  • Bremer M; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
  • Galanter J; Department of Safety Science, Genentech, Inc., South San Francisco, California, USA.
  • Yoshida K; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
  • Smith J; Department of Biostatistics, F. Hoffmann-La Roche, Mississauga, Ontario, Canada.
  • Banerjee P; Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, USA.
  • Sverkos V; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA.
  • Cai F; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
  • Steffen V; Department of Biostatistics, Genentech, Inc., South San Francisco, California, USA.
  • Henderson LM; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
  • Rhee H; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
  • Belloni PN; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
  • Lin JH; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
  • Staton TL; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
Clin Transl Sci ; 15(2): 451-463, 2022 02.
Article in En | MEDLINE | ID: mdl-34581002
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Clin Transl Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Clin Transl Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States