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Is developmental synchrony enabled by CTCF residence time?
Wang, Hsiao-Lin V; Corces, Victor G.
Affiliation
  • Wang HV; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Corces VG; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: vcorces@emory.edu.
Dev Cell ; 56(18): 2545-2546, 2021 09 27.
Article in En | MEDLINE | ID: mdl-34582771
ABSTRACT
Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2021 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2021 Document type: Article Affiliation country: United States