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Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda, Shinichi; Narendran, Siddharth; Varshney, Akhil; Nagasaka, Yosuke; Wang, Shao-Bin; Ambati, Kameshwari; Apicella, Ivana; Pereira, Felipe; Fowler, Benjamin J; Yasuma, Tetsuhiro; Hirahara, Shuichiro; Yasuma, Reo; Huang, Peirong; Yerramothu, Praveen; Makin, Ryan D; Wang, Mo; Baker, Kirstie L; Marion, Kenneth M; Huang, Xiwen; Baghdasaryan, Elmira; Ambati, Meenakshi; Ambati, Vidya L; Banerjee, Daipayan; Bonilha, Vera L; Tolstonog, Genrich V; Held, Ulrike; Ogura, Yuichiro; Terasaki, Hiroko; Oshika, Tetsuro; Bhattarai, Deepak; Kim, Kyung Bo; Feldman, Sanford H; Aguirre, J Ignacio; Hinton, David R; Kerur, Nagaraj; Sadda, Srinivas R; Schumann, Gerald G; Gelfand, Bradley D; Ambati, Jayakrishna.
Affiliation
  • Fukuda S; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Narendran S; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Varshney A; Department of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
  • Nagasaka Y; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Wang SB; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Ambati K; Aravind Eye Hospital System, Madurai, India.
  • Apicella I; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Pereira F; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Fowler BJ; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Yasuma T; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Hirahara S; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yasuma R; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Huang P; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Yerramothu P; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Makin RD; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Wang M; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Baker KL; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Marion KM; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Huang X; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Baghdasaryan E; Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
  • Ambati M; Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, USA.
  • Ambati VL; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Banerjee D; Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
  • Bonilha VL; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Tolstonog GV; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Held U; Department of Ophthalmology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Ogura Y; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Terasaki H; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Oshika T; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Bhattarai D; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Kim KB; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Feldman SH; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
  • Aguirre JI; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Hinton DR; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Kerur N; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Sadda SR; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Schumann GG; Doheny Eye Institute, Los Angeles, CA, USA.
  • Gelfand BD; Doheny Eye Institute, Los Angeles, CA, USA.
  • Ambati J; Doheny Eye Institute, Los Angeles, CA, USA.
Sci Adv ; 7(40): eabj3658, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34586848
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Sci Adv Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States
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Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Sci Adv Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States