Translational opportunities in animal and human models to study alcohol use disorder.
Transl Psychiatry
; 11(1): 496, 2021 09 29.
Article
in En
| MEDLINE
| ID: mdl-34588417
ABSTRACT
Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that human laboratory models provide a "bridge" between preclinical and clinical studies of AUD by allowing for well-controlled experimental manipulations in humans with AUD. As such, examining the consilience between experimental models in animals and humans in the laboratory provides unique opportunities to refine the translational utility of such models. The overall goal of the present review is to provide a systematic description and contrast of commonly used animal paradigms for the study of AUD, as well as their human laboratory analogs if applicable. While there is a wide breadth of animal species in AUD research, the paradigms discussed in this review rely predominately on rodent research. The overarching goal of this effort is to provide critical analysis of these animal models and to link them to human laboratory models of AUD. By systematically contrasting preclinical and controlled human laboratory models, we seek to identify opportunities to enhance their translational value through forward and reverse translation. We provide future directions to reconcile differences between animal and human work and to improve translational research for AUD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alcoholism
Limits:
Animals
/
Humans
Language:
En
Journal:
Transl Psychiatry
Year:
2021
Document type:
Article
Affiliation country:
United States