Selection for or against escape from nonsense mediated decay is a novel signature for the detection of cancer genes.

Kumar, Runjun D; Burns, Briana A; Vandeventer, Paul J; Luna, Pamela N; Shaw, Chad A

Kumar, Runjun D; Burns, Briana A; Vandeventer, Paul J; Luna, Pamela N; Shaw, Chad A.

Affiliation

Kumar RD; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS225, Houston, TX 77030, United States.
Burns BA; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS225, Houston, TX 77030, United States.
Vandeventer PJ; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS225, Houston, TX 77030, United States.
Luna PN; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS225, Houston, TX 77030, United States.
Shaw CA; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS225, Houston, TX 77030, United States; Baylor Genetics, Houston, TX, United States; Department of Statistics, Rice University, Houston, TX, United States. Electronic address: cashaw@bcm.edu.

Cancer Genet ; 258-259: 80-84, 2021 11.

Article in En | MEDLINE | ID: mdl-34592632

Subject(s)

Biomarkers, Tumor/genetics; Codon, Nonsense; Genome, Human; Neoplasms/pathology; Nonsense Mediated mRNA Decay; Phenotype; Humans; Neoplasms/genetics; Prognosis

Key words

Cancer genes; Cancer genomics; DNA sequencing; Frameshift; Nonsense mediated decay

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Biomarkers, Tumor / Genome, Human / Codon, Nonsense / Nonsense Mediated mRNA Decay / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Cancer Genet Year: 2021 Document type: Article Affiliation country: United States

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