Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma.
Cancer Discov
; 11(10): 2375-2377, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34598951
ABSTRACT
Reduced protein expression of the BAF complex (also known as SWI/SNF) tumor suppressor SMARCB1 is frequently observed in human synovial sarcoma, a soft-tissue malignancy driven by the oncogenic SS18-SSX fusion, which competes with wild-type SS18 for BAF complex incorporation. In this issue of Cancer Discovery, Li and Mulvihill reveal that low-expressed SMARCB1 has a functional role in synovial sarcomagenesis in mouse models expressing the SS18-SSX2 fusion and present evidence that SMARCB1 reduction in synovial sarcoma is due to wholesale degradation of canonical BAF complexes.See related article by Li et al., p. 2620.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoma, Synovial
Limits:
Animals
Language:
En
Journal:
Cancer Discov
Year:
2021
Document type:
Article