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Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions.
Kimoto, Emi; Costales, Chester; West, Mark A; Bi, Yi-An; Vourvahis, Manoli; David Rodrigues, A; Varma, Manthena V S.
Affiliation
  • Kimoto E; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
  • Costales C; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
  • West MA; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
  • Bi YA; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
  • Vourvahis M; Clinical Pharmacology, Global Product Development, Pfizer Inc, New York, New York, USA.
  • David Rodrigues A; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
  • Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.
Clin Pharmacol Ther ; 111(2): 404-415, 2022 02.
Article in En | MEDLINE | ID: mdl-34605015
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coproporphyrins / Liver-Specific Organic Anion Transporter 1 / Membrane Transport Modulators / Rosuvastatin Calcium / Atorvastatin / Liver / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coproporphyrins / Liver-Specific Organic Anion Transporter 1 / Membrane Transport Modulators / Rosuvastatin Calcium / Atorvastatin / Liver / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States