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Expanding Bromodomain Targeting into Neglected Parasitic Diseases.
Tallant, Cynthia; Bamborough, Paul; Chung, Chun-Wa; Gamo, Francisco Javier; Kirkpatrick, Robert; Larminie, Chris; Martín, Julio; Prinjha, Rab; Rioja, Inmaculada; Simola, Daniel F; Gabarró, Raquel; Calderón, Félix.
Affiliation
  • Tallant C; Global Health R&D, GlaxoSmithKline, c/ Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Bamborough P; Molecular Design, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Chung CW; Protein, Cellular and Structural Sciences, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Gamo FJ; Global Health R&D, GlaxoSmithKline, c/ Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Kirkpatrick R; GlaxoSmithKline R&D, 1250 S. Collegeville Rd., Collegeville, Pennsylvania 19426, United States.
  • Larminie C; Human Genetics, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Martín J; Global Health R&D, GlaxoSmithKline, c/ Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Prinjha R; Immunology Research Unit, Research, R&D GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Rioja I; Immunology Research Unit, Research, R&D GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Simola DF; Human Genetics and Computational Biology, GlaxoSmithKline, 1250 S. Collegeville Rd., Collegeville, Pennsylvania 19426, United States.
  • Gabarró R; Global Health R&D, GlaxoSmithKline, c/ Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Calderón F; Global Health R&D, GlaxoSmithKline, c/ Severo Ochoa 2, 28760 Tres Cantos, Spain.
ACS Infect Dis ; 7(11): 2953-2958, 2021 11 12.
Article in En | MEDLINE | ID: mdl-34612618
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasitic Diseases / Neglected Diseases Limits: Humans Language: En Journal: ACS Infect Dis Year: 2021 Document type: Article Affiliation country: Spain Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasitic Diseases / Neglected Diseases Limits: Humans Language: En Journal: ACS Infect Dis Year: 2021 Document type: Article Affiliation country: Spain Country of publication: United States