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Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury.
Amo-Aparicio, Jesus; Garcia-Garcia, Joana; Puigdomenech, Maria; Francos-Quijorna, Isaac; Skouras, Damaris B; Dinarello, Charles A; Lopez-Vales, Ruben.
Affiliation
  • Amo-Aparicio J; Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
  • Garcia-Garcia J; Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain.
  • Puigdomenech M; Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain.
  • Francos-Quijorna I; Regeneration Group, Wolfson Centre for Age-Related Diseases, IoPPN, King's College London, London, UK.
  • Skouras DB; Olatec Therapeutics LLC, New York, NY 10065, USA.
  • Dinarello CA; Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA; Department of Medicine, Radboud University Medical Center, 6500 Nijmegen, the Netherlands.
  • Lopez-Vales R; Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain. Electronic address: Ruben.lopez@uab.cat.
Exp Neurol ; 347: 113889, 2022 01.
Article in En | MEDLINE | ID: mdl-34624330
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Sulfones / Inflammasomes / Anti-Inflammatory Agents / Myelin Sheath / Nitriles Limits: Animals Language: En Journal: Exp Neurol Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Sulfones / Inflammasomes / Anti-Inflammatory Agents / Myelin Sheath / Nitriles Limits: Animals Language: En Journal: Exp Neurol Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States