The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults.
Int J Hyg Environ Health
; 238: 113858, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34634756
ABSTRACT
BACKGROUND:
A growing body of evidence has confirmed the association between fine particulate matter (PM2.5) and ocular diseases, but little is known on the effect of long-term PM2.5 exposure on glaucoma.METHODS:
A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM2.5 concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM2.5 exposure with glaucoma and its subtypes.RESULTS:
Estimated PM2.5 concentrations ranged from 28.0 to 96.4 µg/m3. For each 10 µg/m3 increment in PM2.5, the adjusted odds ratios (ORs) were 1.07 (95% CI 1.00-1.15) and 1.14 (95% CI 1.02-1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI 0.92-1.18) was detected between long-term exposure to PM2.5 and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM2.5.CONCLUSIONS:
Long-term PM2.5 exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM2.5.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glaucoma, Open-Angle
/
Air Pollutants
/
Air Pollution
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Hyg Environ Health
Journal subject:
SAUDE AMBIENTAL
/
SAUDE PUBLICA
Year:
2021
Document type:
Article
Affiliation country:
China