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BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome.
Gorombei, Petra; Guidez, Fabien; Ganesan, Saravanan; Chiquet, Mathieu; Pellagatti, Andrea; Goursaud, Laure; Tekin, Nilgun; Beurlet, Stephanie; Patel, Satyananda; Guerenne, Laura; Le Pogam, Carole; Setterblad, Niclas; de la Grange, Pierre; LeBoeuf, Christophe; Janin, Anne; Noguera, Maria-Elena; Sarda-Mantel, Laure; Merlet, Pascale; Boultwood, Jacqueline; Konopleva, Marina; Andreeff, Michael; West, Robert; Pla, Marika; Adès, Lionel; Fenaux, Pierre; Krief, Patricia; Chomienne, Christine; Omidvar, Nader; Padua, Rose Ann.
Affiliation
  • Gorombei P; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Guidez F; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Ganesan S; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Chiquet M; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Pellagatti A; Blood Cancer UK Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Haematology Theme, Oxford OX3 9DU, UK.
  • Goursaud L; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Tekin N; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Beurlet S; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Patel S; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Guerenne L; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Le Pogam C; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Setterblad N; Imagerie Département, Université de Paris, Institut de la Recherche Saint-Louis, 75010 Paris, France.
  • de la Grange P; GenoSplice Technology, Paris Biotech Santé, 29 Rue du Faubourg Saint-Jacques, 75014 Paris, France.
  • LeBoeuf C; INSERM UMR-S942, Université de Paris, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Janin A; INSERM UMR-S942, Université de Paris, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Noguera ME; Department of Cytology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Sarda-Mantel L; Radiopharmacie AP-HP, Hôpital Saint-Louis, Service Medicine Nuclear, AP-HP Lariboisiere, 75010 Paris, France.
  • Merlet P; Nuclear Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Boultwood J; Blood Cancer UK Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Haematology Theme, Oxford OX3 9DU, UK.
  • Konopleva M; M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.
  • Andreeff M; M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.
  • West R; Department of Public Health, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
  • Pla M; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Adès L; INSERM UMR-S944, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Fenaux P; INSERM UMR-S944, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, 75010 Paris, France.
  • Krief P; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Chomienne C; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
  • Omidvar N; Department of Haematology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
  • Padua RA; INSERM UMR-S1131, Université de Paris, Institut de la Recherche Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis Hôpital, 75010 Paris, France.
Int J Mol Sci ; 22(19)2021 Sep 30.
Article in En | MEDLINE | ID: mdl-34638998
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Sulfonamides / Biphenyl Compounds / Myelodysplastic Syndromes / Signal Transduction / Gene Expression Regulation / Proto-Oncogene Proteins c-bcl-2 / Monomeric GTP-Binding Proteins / Nitrophenols Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: France Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Sulfonamides / Biphenyl Compounds / Myelodysplastic Syndromes / Signal Transduction / Gene Expression Regulation / Proto-Oncogene Proteins c-bcl-2 / Monomeric GTP-Binding Proteins / Nitrophenols Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: France Country of publication: Switzerland