Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy.
Eur Radiol
; 32(3): 1931-1938, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-34642808
ABSTRACT
OBJECTIVE:
To evaluate the ability of quantitative MRI parameters for predicting dysthyroid optic neuropathy (DON).METHODS:
We retrospectively collected and analyzed the clinical features and 3.0 T MRI data of 59 patients with Graves orbitopathy (GO), with (n = 26) and without DON (n = 33). We compared MRI quantitative parameters, including the modified muscle index (mMI), proptosis, volume of intra-orbital fat, mean apparent diffusion coefficient value, and T2 value of the optic nerve among patients with and without DON. A logistic regression analysis was performed to identify the risk factors associated with DON. Moreover, we performed a receiver operating characteristic curve analysis and decision curve analysis to evaluate the diagnostic performance of the identified parameters for DON.RESULTS:
We studied 118 orbits (43 and 75 with and without DON, respectively). The mMI and mean T2 value of the optic nerve were significantly greater in orbits with DON (p < 0.001). A greater mMI at 21 mm (odds ratio (OR), 1.039; 95% confidence interval (CI) 1.019, 1.058) and higher mean T2 value of the optic nerve (OR, 1.035; 95% CI 1.017, 1.054) were associated with a higher risk of DON. A model combining the mMI at 21 mm and mean T2 values for the optic nerve effectively predicted DON in patients with GO, with a sensitivity and specificity of 95.3% and 76%, respectively.CONCLUSION:
A quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve can be an effective imaging marker for identifying DON. KEY POINTS ⢠Patients with GO and DON had greater mMI than those without DON. ⢠Optic nerves in patients with DON demonstrated an increased T2 value. ⢠The quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve is the most effective method for diagnosing DON.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Optic Nerve Diseases
/
Graves Ophthalmopathy
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Eur Radiol
Journal subject:
RADIOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
China