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Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment".
Maricic, Tomislav; Helmbrecht, Nelly; Riesenberg, Stephan; Macak, Dominik; Kanis, Philipp; Lackner, Martin; Pugach-Matveeva, Agrafena Daria; Pääbo, Svante.
Affiliation
  • Maricic T; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Helmbrecht N; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Riesenberg S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Macak D; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Kanis P; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Lackner M; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Pugach-Matveeva AD; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Pääbo S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Science ; 374(6565): eabi6060, 2021 Oct 15.
Article in En | MEDLINE | ID: mdl-34648345
ABSTRACT
Trujillo et al. (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoids Language: En Journal: Science Year: 2021 Document type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoids Language: En Journal: Science Year: 2021 Document type: Article Affiliation country: Germany